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ea0029p704 | Diabetes | ICEECE2012

Pathway Integration of Pro-Inflammatory Cytokines, 12-Lipoxygenase and NADPH Oxidase in Beta Cell Dysfunction; Protection by Novel Selective 12-Lipoxygenase Inhibitors.

Taylor-Fishwick D. , Weaver J. , Ganesha B. , Holman T. , Jadhav A. , Maloney D. , Nadler J. , Simeonov A.

In this study we explore and integrate a pathway for loss of functional beta cell mass in diabetes. Inflammatory cytokines induce human islet dysfunction, elevate expression of 12-lipoxygenase, increase cellular reactive species and induce NADPH oxidase. These pathways are elevated in islets from diabetic donors.NADPH oxidase-1 (NOX-1) is significantly induced in either human donor islets, primary mouse islets or homogeneous beta cell lines following sti...

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ea0054is4 | (1) | NuclearReceptors2018

Estrogen receptor cistromics in breast tumors: from biomarkers to novel drug targets

Flach Koen Dorus , Periyasamy Manikandan , Jadhav Ajit , Hickey Theresa E , Opdam Mark , Patel Hetal , Canisius Sander , Wilson David M , Dorjsuren Dorjbal , Nieuwland Marja , Kluin Roel , Zakharov Alexey V , Wesseling Jelle , Wessels Lodewyk Frederik Ary , Linn Sabine Charlotte , Tilley Wayne D , Simeonov Anton , Ali Simak , Zwart Wilbert

Estrogen receptor α (ERα) is a key transcriptional regulator in the majority of breast cancers. ERα-positive patients are frequently treated with tamoxifen, but resistance is common. Through ChIP-seq analyses, we presviously identified direct target genes of ERα acting in complex with SRC1, SRC2 or SRC3 (Zwart et al., 2011 EMBO J). Only the 111 genes there were under direct control of ERα in conjunction with SRC3 (but not the other two p160s) predicted...

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Endocrine Abstracts

Pathway Integration of Pro-Inflammatory Cytokines, 12-Lipoxygenase and NADPH Oxidase in Beta Cell Dysfunction; Protection by Novel Selective 12-Lipoxygenase Inhibitors.

Estrogen receptor cistromics in breast tumors: from biomarkers to novel drug targets

BiosciAbstracts